LINEAR INTERACTION BETWEEN REPLICATION AND TRANSCRIPTION SHAPES DNA BREAK DYNAMICS AT RECURRENT DNA BREAK CLUSTERS

Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters

Abstract Recurrent DNA break clusters (RDCs) are replication-transcription collision hotspots; many are unique to neural progenitor cells.Through high-resolution replication sequencing and a capture-ligation assay in mouse neural progenitor cells experiencing replication stress, we unravel the replication features dictating RDC location and orienta

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The evolving role of radiation in pancreatic cancer

Pancreatic cancer is the fourth leading cause of cancer mortality in the United States.Chemotherapy in resectable pancreatic cancer has improved survival by Bed Pans 10-20%.It only converted 10-30% of the borderline resectable and locally advanced pancreatic cancers to be surgically resectable.Radiation therapy has a documented role in managing loc

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What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?

The T helper cell type 1 (Th1) response is essential to resist leishmaniasis, whereas the Th2 response favors the disease.However, many leishmanial antigens, which stimulate a Th1 Womens ponchos immune response during the disease or even after the disease is cured, have been shown to have no protective action.Paradoxically, antigens associated with

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Individual and Institutional Dimensions of Epistemic Injustice in Swiss Legal Education: Remarks and Ways Forward

In Switzerland, institutions through which legal knowledge and education are produced have systemi-cally enabled epistemic injustice through forms of silencing and the cultivation of active ignorance along individual and institutional dimensions.As such, we argue that an important Hockey Skates - Senior - Performance form of intervention in the leg

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